Statistics Collaborative - Design and analysis for biomedical research


Aparna Anderson, Ph.D.
Vice President and Chief Operating Officer

Aparna Anderson, Ph.D., joined Statistics Collaborative, Inc. (SCI) in 2016 as Vice President and Chief Operating Officer. She has extensive experience as a clinical trialist across a range of therapeutic areas through the roles she held at the Bristol-Myers Squibb Company (BMS) from 1997 to 2016. Prior to joining BMS, she was an Assistant Professor in the Division of Biostatistics at the University of Minnesota from 1995 to 1997.

During her tenure at BMS, Dr. Anderson contributed to clinical trial design, interpretation of trial results, conference presentations and manuscripts, diagnostic development, and health authority interactions. She brought statistical and scientific perspectives to pipeline strategy, including proof-of-concept transition product development, due diligence for in-licensing and acquisitions, go/no-go decision-making, and phase 3 trial design. She has interacted with regulators (e.g., FDA, EMA, and Health Canada) for end-of-phase 2 and development discussions, pre- and post-submission meetings, and advisory committee presentations.

Dr. Anderson provided statistical leadership for the clinical development of ipilimumab and nivolumab, two pioneering therapies in the field of immuno-oncology. Her contributions to the ipilimumab melanoma trial designs resulted in global approvals for first- and second-line metastatic melanoma as well as adjuvant melanoma. During this period, she also collaborated with an interdisciplinary team of scientists in the first effort to define alternative response criteria to address response kinetics unique to immuno-oncology agents.

As the lead statistician for late stage development of nivolumab, Dr. Anderson led her team to conduct scientific evaluations to select appropriate endpoints and timing of interim analyses that resulted in early decisions for five separate indications: melanoma, squamous and non-squamous non-small cell lung cancer, head and neck cancer, and renal cell carcinoma. For these contributions, BMS recognized Dr. Anderson in 2016 with the James B. D. Palmer Award for Excellence in Drug Development, a prestigious award celebrating innovative drug development achievements that significantly advance Research and Development goals.

Prior to her work in oncology, she supported antibiotic clinical trials by applying non-inferiority methods for registration in respiratory and skin infections, developing statistical analysis plans for study-level and integrated analyses, and contributing to clinical components of Common Technical Documents.

While at the University of Minnesota, she taught courses in multiple linear regression and longitudinal data analysis, collaborated in grant submissions at the Center on Aging, and was part of an advisory panel for violence prevention grant-based research.

Dr. Anderson received a B.S. in Applied Mathematics from the University of California, Davis (1989) and her M.S. and Ph.D. in Biostatistics from the University of Washington (1995). In 1989-1990, she spent a year studying mathematics as a Fulbright scholar at the University of Göttingen, Federal Republic of Germany.